Kerwin, Sean

Sean M Kerwin

Adjunct Associate Professor
College of Pharmacy

Phone: 512-471-5074

Office Location
BME 6.202C

Postal Address
The University of Texas at Austin
College of Pharmacy
1 University Station A1900
Austin, TX 78712

The long-term goal of our research is the development of selective strategies for the treatment of cancer, inflammation, and infectious diseases. Our work takes place at the interface of computational chemistry, synthesis, biochemistry, and molecular biology. The targets of current interest include certain nucleic acid sequences and their associated structures, such as G-quadruplexes, kinases implicated in cancer and inflammation, and as yet undefined targets of structurally and functionally interesting anti-cancer and anti-inflammitory natural products . Structural and biochemical characterization of these targets enables us to use computational and combinatorial chemistry techniques to discover compounds that combine recognition of the targets with the desired biological effects.

Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: effects on heme oxygenase-1 induction and antioxidant activities (2010) Eur J Pharmacol. 635, 16-22.

Cyclization kinetics and biological evaluation of an anticancer 1,2-dialkynylimidazole. (2010) Org Biomol Chem. 8, 1535-9.

Synthesis and biological evaluation of p38alpha kinase-targeting dialkynylimidazoles (2009) Bioorg Med Chem Lett. 19, 6293-7.

Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1. (2008) Bioorg Med Chem. 16, 1775-83.

Simian virus 40 large T-antigen G-quadruplex DNA helicase inhibition by G-quadruplex DNA-interactive agents. (2008) Biochemistry 47, 1896-909.