Aaron B BakerAssociate Professor
Fellow of Marion E. Forsman Centennial Professorship in Engineeringabbaker@austin.utexas.edu
The University of Texas at Austin
Biomedical Engineering, Cockrell School of Engineering
107 W. Dean Keeton
Austin, TX 78712
Dr. Baker specializes in cardiovascular biology—specifically devices and interventional technologies to prevent atherosclerosis and restenosis. His research focuses on vascular mechanotransduction, or the study of cell and tissue responses to mechanical forces. Additionally, his lab works to advance vascular drug delivery and testing of drugs to be used for vessel regrowth and heart revascularization.
Baker AB, Gibson W, Kolachalama VB, Golumb M, Indolfi L, Zcharia E, Vlodavsky I, Edelman ER: Heparanase Regulates the Thrombosis in Vascular Injury and Stenting (in press at the Journal of American College of Cardiology).
Jang E, Abawadi H, Watkins M, Edelman ER, Baker AB: Syndecan-4 Proteoliposomes Enhance FGF-2 Induced Proliferation, Migration and Neovascularization of Ischemic Muscle (in press at the Proceedings of the National Academy of Sciences).
Franses JW, Baker AB, Chitalia VC, Edelman ER: Stromal Endothelial Cells Directly Regulate Cancer Phenotype. Science Translational Medicine 3(66):66ra5, 2011.
Chatzizisis YS*, Baker AB*, Beigel R, Jonas M, M, Coskun AU, Stone BV, Maynard C, Gerrity RG, Feldman CL, Stone PH, and Edelman ER: Upregulation of Extracellular Matrix Degrading Enzymes by Low Endothelial Shear Stress In Vivo Promotes the Formation of Coronary Thin Cap Fibroatheromas. Circulation 123(6):621-30, 2011.
Baker AB, Chatzizisis YS, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C, Rogers C, Feldman CL, Stone PH and Edelman ER: The Role of Heparanase in the Natural History of Atherosclerotic Plaque Development. Atherosclerosis 213(2):436-42, 2010.
Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Cir Res 2009 Feb; 104(3); 380-387.
Baker AB, Ettenson D, Jonas M, Nugent M, Iozzo R, Edelman ER. Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF2-beta signaling pathway. Cir Res 2008 Aug; 103(3); 289-297.