HARRIS, R ADRON

R A Harris

Professor
Department of Neuroscience, College of Pharmacy

M. June and J. Virgil Waggoner Chair in Molecular Biology

Investigating molecular mechanisms responsible for alcoholism and drug dependence.

harris@austin.utexas.edu

Phone: 512-232-2514

Office Location
MBB 1.124

Postal Address
The University of Texas at Austin
Department of Neuroscience, College of Natural Sciences
1 University Station C7000
Austin, TX 78712

Dr. R. Adron Harris is Director of the Waggoner Center for Alcohol and Addiction Research and holds the M. June and J. Virgil Waggoner Chair in Molecular Biology.  Dr. Harris is author or co-author of more than 350 papers on the molecular biology of alcohol and the human nervous system. He is the recipient of the MERIT Award from the National Institute on Alcohol Abuse and Alcoholism, the Outstanding Reseacher of the Year Award from the Research Society on Alcoholism, and the Jellinek Memorial Award, an international prize given each year to the scientist who has made the greatest contribution to the understanding of alcoholism as a disease.

Research Summary: 
This laboratory is investigating molecular mechanisms responsible for alcoholism and drug dependence. We are defining actions of alcohol and other drugs on brain cells as well as the long-term changes in gene expression responsible for tolerance and dependence. The ion channels controlling neuronal excitability are of particular importance in our studies. Another aspect is the neurochemical basis for genetic differences in drug response. These experiments use genetically modified mice that vary in susceptibility to drug intoxication and dependence. A student working in this laboratory would carry out some of the following studies: (a) effects of drugs on ion channels; (b) site-directed mutagenesis of ion channels; (c) functional and structural studies of brain neurotransmitter receptors; (d) gene expression profiles of humans and mice using microarrays and RNAseq.

Investigators at the Waggoner Center for Alcohol and Addiction Research provide wide-ranging academic approaches to alcohol and addiction research. These research directives include studies of neural plasticity, molecular actions of alcohols and anesthetics, gene expression, and addictive behaviors.

Peer-Reviewed Journal Articles

2015  Most D, Leiter C, Blednov YA, Harris RA, Mayfield RD.. Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption.  Neuropsychopharmacology.  doi: 10.1038/npp.2015.179.

2015  Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV. Brain pathways to recovery from alcohol dependence.  Alcohol.  49(5):435-52.

2015  Farris SP, Harris RA, Ponomarev I.  Epigenetic modulation of brain genenetworks for cocaine and alcohol abuse.  Front. Neurosci.  9:176.  doi: 10.3389/fnins.2015.00176.

2015  Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.  Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.  Alcohol Clin Exp Res.  39(6):962-8.

2015  Blednov YA, Benavidez JM, Black M, Mayfield J, Harris RA.  Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines.  Neuropharmacology.  95:309-20.

2015  Farris SP, Pietrzykowski AZ, Miles MF, O'Brien MA, Sanna PP, Zakhari S, Mayfield RD, Harris RA.  Applying the new genomics to alcohol dependence.  Alcohol.  [Epub ahead of print]:  doi: 10.1016/j.alcohol.2015.03.001.

2015  Osterndorff-Kahanek EA, Becker HC, Lopez MF, Farris SP, Tiwari GR, Nunez YO, Harris RA, Mayfield RD.  Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks.  PLoS One.  10(3):e0121522.  doi: 10.1371/journal.pone.0121522.

2015  Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Harris RA..  Glycine Receptors Containing α2 or α3 Subunits Regulate Specific Ethanol-Mediated Behaviors.  J Pharmacol Exp Ther.  353(1):181-91.

2015  Blednov YA, Benavidez JM, Black M, Ferguson LB, Schoenhard GL, Goate AM, Edenberg HJ, Wetherill L, Hesselbrock V, Foroud T, Harris RA.  Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.  Alcohol Clin Exp Res.  39(1):136-45.

2015  Bajo M, Herman MA, Varodayan FP, Oleata CS, Madamba SG, Harris RA, Blednov YA, Roberto M.  Role of the IL-1 receptor antagonist in ethanol-induced regulation of GABAergic transmission in the central amygdala.  Brain Behav Immun.  45:189-97.

2015  Most D, Ferguson L, Blednov Y, Mayfield RD, Harris RA.  The synaptoneurosome transcriptome: a model for profiling the molecular effects of alcohol.  Pharmacogenomics J.  15(2):177-88.

2014 Blednov YA, Benavidez JM, Black M, Harris RA.  Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front. Neurosci. doi: 10.3389/fnins.2014.00129.

2014 Trudell JR, Messing RO, Mayfield J, Harris RA. Alcohol dependence: molecular and behavioral evidence. Trends Pharmacol Sci. doi: 10.1016/j.tips.2014.04.009.

2014 Lee C, Mayfield RD, Harris RA. Altered gamma-aminobutyric Acid type B receptor subunit 1 splicing in alcoholics. Biol Psychiatry. 75:765-7.

2014 Bajo M, Madamba SG, Roberto M, Blednov YA, Sagi VN, Roberts E, Rice KC, Harris RA, Siggins GR. Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala. Brain Behav Immun. doi: 10.1016/j.bbi.2014.03.007.

2014 Howard RJ, Trudell JR, Harris RA. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacol Rev. 66:396-412.

2014 Borghese CM, Hicks JA, Lapid DJ, Trudell JR, Harris RA. GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites. J Neurochem. 128:363-75.

2014 Gorini G, Harris RA, Mayfield RD. Proteomic approaches and identification of novel therapeutic targets for alcoholism. Neuropsychopharmacology. 39:104-30.

2014 Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Johnson D, Borghese CM, Hanrahan JR, Johnston GA, Chebib M, Harris RA. GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice. PLoS One. 9:e85525.

2013 Ferguson C, McKay M, Harris RA, Homanics GE. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Alcohol. 47:595-7.

2013 Nunez YO, Truitt JM, Gorini G, Ponomareva ON, Blednov YA, Harris RA, Mayfield RD. Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. BMC Genomics. 14:725.

2013 Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA. Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels. Mol Pharmacol. 84:670-8.

2013 McCracken LM, Trudell JR, McCracken ML, Harris RA. Zinc-dependent modulation of alpha2- and alpha3-glycine receptor subunits by ethanol. Alcohol Clin Exp Res. 37:2002-10.

2013 Bromstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E. Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites. Structure. 21:1307-16.

2013 Lee C, Harris RA, Wall JK, Mayfield RD, Wilke CO. RNaseIII and T4 Polynucleotide Kinase sequence biases and solutions during RNA-seq library construction. Biol Direct. 8:16.

2013 Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M. Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun. 4:1697.

2013 Osterndorff-Kahanek E, Ponomarev I, Blednov YA, Harris RA. Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation. PLoS One. 8:e59870.

2013 Eberhart JK, Harris RA. Understanding variability in ethanol teratogenicity. Proc Natl Acad Sci U S A. 110:5285-6.

2013 Mayfield J, Ferguson L, Harris RA. Neuroimmune signaling: a key component of alcohol abuse. Curr Opin Neurobiol. 23:513-20.

2013 Ozburn AR, Harris RA, Blednov YA. Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice. Pharmacol Biochem Behav. 104:33-9.

2013 McCracken LM, Blednov YA, Trudell JR, Benavidez JM, Betz H, Harris RA. Mutation of a zinc-binding residue in the glycine receptor alpha1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. J Pharmacol Exp Ther. 344:489-500.

2013 Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA. Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology. 67:46-56.

2012 Reilly MT, Harris RA, Noronha A. Using genetically engineered animal models in the postgenomic era to understand gene function in alcoholism. Alcohol Res. 34:282-91.

2012 Borghese CM, Harris RA. Alcohol Dependence and Genes Encoding alpha2 and gamma1 GABAA Receptor Subunits: Insights from Humans and Mice. Alcohol Res. 34:345-53.

2012 Ozburn AR, Mayfield RD, Ponomarev I, Jones TA, Blednov YA, Harris RA. Chronic self-administration of alcohol results in elevated Delta FosB: comparison of hybrid mice with distinct drinking patterns. BMC Neurosci. 13:130.

2012 Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E. Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. PLoS Comput Biol. 8:e1002710.

2012 Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolarconcentration in knockin mice. Anesthesiology. 117:765-71.

2012 Blednov YA, Mayfield RD, Belknap J, Harris RA. Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data. Genes Brain Behav. 11:424-35.

2012 Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD. Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci. 32:1884-97.

2012 Johnson WD 2nd, Howard RJ, Trudell JR, Harris RA. The TM2 6' position of GABA(A) receptors mediates alcohol inhibition. J Pharmacol Exp Ther. 340:445-56.

2012 Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Characterization of two mutations, M287L and Q266I, in the alpha1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther. 340:304-16.

2012 Blednov YA, Benavidez JM, Homanics GE, Harris RA. Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor alpha1 subunit. J Pharmacol Exp Ther. 340:317-29.

2011 Etheridge N, Mayfield RD, Harris RA, Dodd PR. Identifying changes in the synaptic proteome of cirrhotic alcoholic superior frontal gyrus. Curr Neuropharmacol. 9:122-8.

2011 Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA. Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A. 108:12149-54.

2011 Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res. 35:1561-73.

2011 Lewohl JM, Nunez YO, Dodd PR, Tiwari GR, Harris RA, Mayfield RD. Up-regulation of microRNAs in brain of human alcoholics. Alcohol Clin Exp Res. 35:1928-37.

2011 Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Jr MC, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD. How Should Addiction-Related Research at the National Institutes of Health be Reorganized? Front Psychiatry. 2:2.

2011 Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD. Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details. Alcohol Clin Exp Res. 35:572-80.

2011 Morikawa H, Harris RA. Small K channels: big targets for treating alcoholism? Biol Psychiatry. 69:614-5.

2010 McCracken LM, McCracken ML, Gong DH, Trudell JR, Harris RA. Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues. ACS Chem Neurosci. 1:482.

2012 Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict Biol. 17:108-20.

2011 Crabbe JC, Harris RA, Koob GF. Preclinical studies of alcohol binge drinking. Ann N Y Acad Sci. 1216:24-40.

2011 Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA. Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun. 25:S92-S105.

2011 Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Harris RA, Ponomarev I. Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcohol Clin Exp Res. 35:659-70.

2010 Lee C, Mayfield RD, Harris RA. Intron 4 containing novel GABAB1 isoforms impair GABAB receptor function. PLoS One. 18:e14044.

2011 Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, Blednov YA. Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor alpha1 and alpha2 subunit knock-in mice. Neurosci Lett. 488:31-5.

2011 Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA. Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive alpha2-containing GABA(A) receptors. J Pharmacol Exp Ther. 336:145-54.

2010 McCracken ML, Borghese CM, Trudell JR, Harris RA. A transmembrane amino acid in the GABAA receptor beta-2 subunit critical for the actions of alcohols and anesthetics. J Pharmacol Exp Ther. 335:600-6.

2011 Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI 2nd, Harrison NL, Harris RA, Homanics GE. Inhaled anesthetic responses of recombinant receptors and knockin mice harboring alpha2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. J Pharmacol Exp Ther. 336:134-44.

2010 Ozburn AR, Harris RA, Blednov YA. Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake. Behav Genet. 40:551-63.

2010 Ponomarev I, Rau V, Eger EI, Harris RA, Fanselow MS. Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder. Neuropsychopharmacology. 35:1402-11.

2010 Gorini G, Ponomareva O, Shores KS, Person MD, Harris RA, Mayfield RD. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. FEBS Lett. 584:845-51.

2010 Zhang Y, Guzinski M, Eger EI 2nd, Laster MJ, Sharma M, Harris RA, Hemmings HC Jr. Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats. Br J Pharmacol. 159:872-8.

2010 Sullivan EV, Harris RA, Pfefferbaum A. Alcohol's Effects on Brain and Behavior. Alcohol Res Health. 33:127-43.

2010 Blednov YA, Walker DL, Iyer SV, Homanics G, Harris RA. Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addict Biol. 15:45-61.

2009 Etheridge N, Lewohl JM, Mayfield RD, Harris RA, Dodd PR. Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain. Proteomics Clin Appl. 3:730-742.

2010 McCracken LM, Trudell JR, Goldstein BE, Harris RA, Mihic SJ. Zinc enhances ethanol modulation of the alpha1 glycine receptor. Neuropharmacology 58:676-81.

2010 Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. Hybrid mice as genetic models of high alcohol consumption. Behav Genet. 40:93-110.

2009 Blednov YA, Harris RA. Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol. Neuropharmacology. 56:814-20.

2008 Harris RA, Eger EI 2nd. Alzheimer's disease and anesthesia: out of body, out of mind...or not? Ann Neurol. 64:595-7.

2009 Mayfield RD, Harris RA. Gene expression profiling in blood: new diagnostics in alcoholism and addiction? Neuropsychopharmacology. 34:250-1.

2008 Horishita T, Eger EI 2nd, Harris RA. The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes. Anesth Analg. 107:1579-86.

2008 Zhang Y, Sharma M, Eger EI 2nd, Laster MJ, Hemmings HC Jr, Harris RA. Intrathecal veratridine administration increases minimum alveolar concentration in rats. Anesth Analg. 107:875-8.

2008 Jenkins A, Lobo IA, Gong D, Trudell JR, Solt K, Harris RA, Eger EI 2nd. General anesthetics have additive actions on three ligand gated ion channels. Anesth Analg. 107:486-93.

2008 Harris RA, Trudell JR, Mihic SJ. Ethanol's molecular targets. Sci Signal. 1:re7.

2008 Ozburn AR, Harris RA, Blednov YA. Wheel running, voluntary ethanol consumption, and hedonic substitution. Alcohol. 42:417-24.

2008 Horishita T, Harris RA. n-Alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes. J Pharmacol Exp Ther. 326:270-7.

2008 Lobo IA, Harris RA. GABA(A) receptors and alcohol. Pharmacol Biochem Behav. 90:90-4.

2008 Blednov YA, Harris RA. Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions. Int J Neuropsychopharmacol. 11:775-93.

2008 Mayfield RD, Harris RA, Schuckit MA. Genetic factors influencing alcohol dependence. Br J Pharmacol. 154:275-87.

2008 Reilly MT, Lobo IA, McCracken LM, Borghese CM, Gong D, Horishita T, Harris RA. Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. Alcohol Clin Exp Res. 32:188-96.

2008 Lobo IA, Harris RA, Trudell JR. Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem. 104:1649-62.

2007 Okvist A, Johansson S, Kuzmin A, Bazov I, Merino-Martinez R, Ponomarev I, Mayfield RD, Harris RA, Sheedy D, Garrick T, Harper C, Hurd YL, Terenius L, Ekstrí_m TJ, Bakalkin G, Yakovleva T. Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. PLoS One. 2:e930.

2007 Liu J, Lewohl JM, Harris RA, Dodd PR, Mayfield RD. Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcohol Clin Exp Res. 32:1460-6.

2007 Borghese CM, Harris RA. Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results. Alcohol. 41:155-62.

2006 Blednov YA, Walker D, Martinez M, Harris RA. Reduced alcohol consumption in mice lacking preprodynorphin. Alcohol. 40:73-86.

2007 Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI 2nd, Homanics GE. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 106:107-13.

2006 Boehm SL 2nd, Ponomarev I, Blednov YA, Harris RA. From gene to behavior and back again: new perspectives on GABAA receptor subunit selectivity of alcohol actions. Adv Pharmacol. 54:171-206.

2007 Blednov YA, Cravatt BF, Boehm SL 2nd, Walker D, Harris RA. Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology. 32:1570-82.

2006 Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF. Alcohol-related genes: contributions from studies with genetically engineered mice. Addict Biol. 11:195-269.

2006 Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Arch Gen Psychiatry. 63:957-68.

2006 Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL 2nd, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. J Pharmacol Exp Ther. 319:208-18.

2006 Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE. Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther. 319:219-27.

2006 Boehm SL 2nd, Homanics GE, Blednov YA, Harris RA. delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. Eur J Pharmacol. 541:158-62.

2006 Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm SL 2nd, Homanics GE, Berman AE, Lodowski KH, Bergeson SE, Harris RA. Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. J Neurosci. 26:5673-83.

2007 Maiya R, Ponomarev I, Linse KD, Harris RA, Mayfield RD. Defining the dopamine transporter proteome by convergent biochemical and in silico analyses. Genes Brain Behav. 6:97-106.

2006 Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI 2nd. The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 102:1419-26.

2006 Ogata J, Shiraishi M, Namba T, Smothers CT, Woodward JJ, Harris RA. Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 318:434-43.

2006 Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A. 103:6368-73.

2006 Jung S, Harris RA. Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors. J Neurochem. 96:885-92.

2005 Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC. Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcohol Clin Exp Res. 29:1949-58.

2006 Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, Mayfield RD. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology. 31:1574-82.

2006 Borghese CM, Storustovu SI, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. J Pharmacol Exp Ther. 316:1360-8.

2005 Dani JA, Harris RA. Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nat Neurosci. 8:1465-70.

2005 Hara K, Yamakura T, Sata T, Harris RA. The effects of anesthetics and ethanol on alpha2 adrenoceptor subtypes expressed with G protein-coupled inwardly rectifying potassium channels in Xenopus oocytes. Anesth Analg. 101:1381-8.

2006 Lobo IA, Trudell JR, Harris RA. Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharmacology. 50:174-81.

2005 Findlay GS, Harris RA, Blednov YA. Male transgenic glycine receptor alpha1 (S267Q) mutant mice display a hyperekplexia-like increase in acoustic startle responses. Pharmacol Biochem Behav. 82:215-22.

2005 Lobo IA, Harris RA. Sites of alcohol and volatile anesthetic action on glycine receptors. Int Rev Neurobiol. 65:53-87.

2005 Blednov YA, Bergeson SE, Walker D, Ferreira VM, Kuziel WA, Harris RA. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res. 165:110-25.

2005 Alling C, Chick JD, Anton R, Mayfield RD, Salaspuro M, Helander A, Harris RA. Revealing alcohol abuse: to ask or to test? Alcohol Clin Exp Res. 29:1257-63.

2005 Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI 2nd. Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg. 101:412-8.

2004 Blednov YA, Walker D, Osterndorf-Kahanek E, Harris RA. Mice lacking metabotropic glutamate receptor 4 do not show the motor stimulatory effect of ethanol. Alcohol. 34:251-9.

2004 Blednov YA, Walker D, Harris RA. Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice. Alcohol Clin Exp Res. 28:1683-92.

2004 Ponomarev I, Schafer GL, Blednov YA, Williams RW, Iyer VR, Harris RA. Convergent analysis of cDNA and short oligomer microarrays, mouse null mutants and bioinformatics resources to study complex traits. Genes Brain Behav. 3:360-8.

2004 Lewohl JM, Van Dyk DD, Craft GE, Innes DJ, Mayfield RD, Cobon G, Harris RA, Dodd PR. The application of proteomics to the human alcoholic brain. Ann N Y Acad  1025:14-26.

2004 Boehm SL 2nd, Peden L, Jennings AW, Kojima N, Harris RA, Blednov YA. Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice. Neurosci Lett. 372:6-11.

2005 Jung S, Akabas MH, Harris RA. Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation. J Biol Chem. 280:308-16.

2004 Boehm SL 2nd, Ponomarev I, Jennings AW, Whiting PJ, Rosahl TW, Garrett EM, Blednov YA, Harris RA. gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem Pharmacol. 68:1581-602.

2004 Liu J, Lewohl JM, Dodd PR, Randall PK, Harris RA, Mayfield RD. Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J Neurochem. 90:1050-8.

2004 Lobo IA, Trudell JR, Harris RA. Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. J Neurochem. 90:962-9.

2004 Zhang Y, Sonner JM, Eger EI 2nd, Stabernack CR, Laster MJ, Raines DE, Harris RA. Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg. 99:85-90.

2004 Lobo IA, Mascia MP, Trudell JR, Harris RA. Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J Biol Chem. 279:33919-27.

2004 Littleton JM, De Witte P, Litten R, Gessa GL, Spanagel R, Kranzler H, Lehert P, Johnson B, Saunders J, Berglund M, Harris RA, Anton R, Mann K. Challenges to medications development in treating alcohol dependence: an international perspective. Alcohol Alcohol. 39:271-5.

2004 Shiraishi M, Harris RA. Effects of alcohols and anesthetics on recombinant voltage-gated Na+ channels. J Pharmacol Exp Ther. 309:987-94.

2004 Boehm SL 2nd, Peden L, Harris RA, Blednov YA. Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits. J Pharmacol Exp Ther. 309:1154-9.

2004 Trudell JR, Harris RA. Are sobriety and consciousness determined by water in protein cavities? Alcohol Clin Exp Res. 28:1-3.

2004 Harris RA, Mihic SJ. Alcohol and inhibitory receptors: unexpected specificity from a nonspecific drug. Proc Natl Acad Sci U S A. 101:2-3.

2003 Mayfield RD, Liu J, Randall PK, Lewohl JM, Dodd PR, Harris RA. Methods for the identification of differentially expressed genes in human post-mortem brain. Methods. 31:301-5.

2003 Borghese CM, Henderson LA, Bleck V, Trudell JR, Harris RA. Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors. J Pharmacol Exp Ther. 307:42-52.

2003 Borghese CM, Wang L, Bleck V, Harris RA. Mutation in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes blocks ethanol action. Addict Biol. 8:313-8.

2003 Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, Harris RA. Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. J Neurosci. 23:8051-9.

2003 Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI 2nd. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. 97:718-40.

2003 Boehm SL 2nd, Peden L, Chang R, Harris RA, Blednov YA. Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol. Alcohol Clin Exp Res. 27:1033-40.

2003 Blednov YA, Walker D, Alva H, Creech K, Findlay G, Harris RA. GABAA receptor alpha 1 and beta 2 subunit null mutant mice: behavioral responses to ethanol. J Pharmacol Exp Ther. 305:854-63.

2003 Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI 2nd, Stabernack CR, Sonner JM. Glycine receptors mediate part of the immobility produced by inhaled anesthetics. Anesth Analg. 96:97-101.

2002 Borghese CM, Ali DN, Bleck V, Harris RA. Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains. Alcohol Clin Exp Res. 26:1764-72.

2003 Blednov YA, Stoffel M, Alva H, Harris RA. A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci U S A. 100:277-82.

2003 Blednov YA, Jung S, Alva H, Wallace D, Rosahl T, Whiting PJ, Harris RA. Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. J Pharmacol Exp Ther. 304:30-6.

2002 Hara K, Eger EI 2nd, Laster MJ, Harris RA. Nonhalogenated alkanes cyclopropane and butane affect neurotransmitter-gated ion channel and G-protein-coupled receptors: differential actions on GABAA and glycine receptors. Anesthesiology. 97:1512-20.

2002 Borghese CM, Harris RA. Anesthetic-induced immobility: neuronal nicotinic acetylcholine receptors are no longer in the picture. Anesth Analg. 95:509-11.

2002 Harris RA, Morrisett RA. Two-shot cocktail: adenosine, dopamine and a twist of beta gamma. Nat Med. 8:777-9.

2002 Maiya R, Buck KJ, Harris RA, Mayfield RD. Ethanol-sensitive sites on the human dopamine transporter. J Biol Chem. 277:30724-9.

2002 Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem. 81:802-13.

2002 Blednov YA, Stoffel M, Cooper R, Wallace D, Mane N, Harris RA. Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels. Psychopharmacology (Berl). 159:370-8.

2002 Hara K, Harris RA. The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels. Anesth Analg. 94:313-8.

2002 Findlay GS, Wick MJ, Mascia MP, Wallace D, Miller GW, Harris RA, Blednov YA. Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice. J Pharmacol Exp Ther. 300:526-34.

2001 Zhang Y, Stabernack CR, Dutton R, Sonner J, Trudell JR, Mihic SJ, Yamakura T, Harris RA, Gong D, Eger EI 2nd. Luciferase as a model for the site of inhaled anesthetic action. Anesth Analg. 93:1246-52.

2001 Blednov YA, Stoffel M, Chang SR, Harris RA. GIRK2 deficient mice. Evidence for hyperactivity and reduced anxiety. Physiol Behav. 74:109-17.

2001 Hara K, Lewohl JM, Yamakura T, Harris RA. Mutational analysis of ethanol interactions with G-protein-coupled inwardly rectifying potassium channels. Alcohol. 24:5-8.

2001 Yamakura T, Lewohl JM, Harris RA. Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels. Anesthesiology. 95:144-53.

2001 Blednov YA, Stoffel M, Chang SR, Harris RA. Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J Pharmacol Exp Ther. 298:521-30.

2001 Ueno S, Harris RA, Messing RO, Sanchez-Perez AM, Hodge CW, McMahon T, Wang D, Mehmert KK, Kelley SP, Haywood A, Olive MF, Buck KJ, Hood HM, Blednov Y, Findlay G, Mascia MP. Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. Alcohol Clin Exp Res. 25:76S-81S.

2001 Eger EI 2nd, Fisher DM, Dilger JP, Sonner JM, Evers A, Franks NP, Harris RA, Kendig JJ, Lieb WR, Yamakura T. Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology. 94:915-21.

2001 Findlay GS, Ueno S, Harrison NL, Harris RA. Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors. Neurosci Lett. 305:77-80.

2001 Yamakura T, Bertaccini E, Trudell JR, Harris RA. Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 41:23-51.

2001 Godden EL, Harris RA, Dunwiddie TV. Correlation between molecular volume and effects of n-alcohols on human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 296:716-22.

2001 Lewohl JM, Dodd PR, Mayfield RD, Harris RA. Application of DNA microarrays to study human alcoholism. J Biomed. 8:28-36.

2000 Yamakura T, Chavez-Noriega LE, Harris RA. Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine. Anesthesiology. 92:1144-53.

2000 Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA. Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res. 24:1873-82.

2000 Zhang Y, Trudell JR, Mascia MP, Laster MJ, Gong DH, Harris RA, Eger EI 2nd. The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis. Anesth Analg. 91:1294-9.

2000 Mascia MP, Gong DH, Eger EI 2nd, Harris RA. The anesthetic potency of propanol and butanol versus propanethiol and butanethiol in alpha1 wild type and alpha1(S267Q) glycine receptors. Anesth Analg. 91:1289-93.

2000 Yamakura T, Borghese C, Harris RA. A transmembrane site determines sensitivity of neuronal nicotinic acetylcholine receptors to general anesthetics. J Biol Chem. 275:40879-86.

2000 Yamakura T, Harris RA. Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology. 93:1095-101.

2000 Ueno S, Lin A, Nikolaeva N, Trudell JR, Mihic SJ, Harris RA, Harrison NL. Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. Br J Pharmacol. 131:296-302.

2000 Wick MJ, Radcliffe RA, Bowers BJ, Mascia MP, Lí_scher B, Harris RA, Wehner JM. Behavioural changes produced by transgenic overexpression of gamma2L and gamma2S subunits of the GABAA receptor. Eur J Neurosci. 12:2634-8.

2000 Baer K, Essrich C, Balsiger S, Wick MJ, Harris RA, Fritschy JM, Lí_scher B. Rescue of gamma2 subunit-deficient mice by transgenic overexpression of the GABAA receptor gamma2S or gamma2L subunit isoforms. Eur J Neurosci. 12:2639-43.

2000 Trudell JR, Bertaccini EA, Eger EI, Harrison NL, Mihic SJ, Harris RA. The interface of molecular modeling and molecular genetics:  a search for sites of anesthetic action.  Prog. Anesth. Mech. 6:172-178.

2000 Mascia MP, Trudell JR, Harris RA. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci U S A. 97:9305-10.

1999 Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA, Harris RA. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci. 2:1084-90.

1999 Cardoso RA, Yamakura T, Brozowski SJ, Chavez-Noriega LE, Harris RA. Human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes predict efficacy of halogenated compounds that disobey the Meyer-Overton rule. Anesthesiology. 91:1370-7.

1999 Harris RA. Ethanol actions on multiple ion channels: which are important? Alcohol Clin Exp Res. 23:1563-70.

1999 Yamakura T, Mihic SJ, Harris RA. Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem. 274:23006-12.

1999 Ueno S, Wick MJ, Ye Q, Harrison NL, Harris RA. Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. Br J Pharmacol. 127:377-82.

1999 Eger EI 2nd, Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR. Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart. Anesth Analg. 88:1395-400.

1999 Cardoso RA, Brozowski SJ, Chavez-Noriega LE, Harpold M, Valenzuela CF, Harris RA. Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 289:774-80.

1999 Ueno S, Trudell JR, Eger EI 2nd, Harris RA. Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis. Anesth Analg. 88:877-83.

1999 Eger EI 2nd, Ionescu P, Laster MJ, Gong D, Hudlicky T, Kendig JJ, Harris RA, Trudell JR, Pohorille A. Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis. Anesth Analg. 88:867-76.

Book Chapters

2014 Marballi K, Ponomarev I, Mayfield RD, Harris RA . Alcohol and the brain: an epigenetic viewpoint.  In Neurobiology of Alcohol Dependence.  Noronha AB, Cui C, Harris RA, Crabbe JC, Eds.  Elsevier Inc. pp. 349-358.

2013 Harris RA, Beldnov YA . Neuroimmune genes and alcohol drinking behavior, in Neural-Immune Interactions.  In Brain Function and Alcohol Related Disorders.  Cui C, Grandison L, Noronha A, Eds.  Springer US. pp. 425-440.

2005 Shiraishi M, Ogata J, Woodward JJ, Harris RA. A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.  In Basic and Systemic Mechanisms of Anesthesia.  Mashimo T, Ogli K, Uchida I, Eds.  Elsevier B.V. pp. 273-274.

2005 Fleming MF, Mihic S, Harris RA. Ethanol.  In Goodman & Gilman’s The Pharmacological Basis of Therapeutics.  Hardman & Limbird, Eds.  McGraw-Hill. pp. 591-606.

2005 Mihic SJ, Harris RA. Hypnotics and Sedatives.  In Goodman & Gilman’s The Pharmacological Basis of Therapeutics.  Hardman & Limbird, Eds.  McGraw-Hill. pp. 401-428.

2005 Lobo IA, Harris RA. Sites of alcohol and volatile anesthetic action on glycine receptors.  In International Review of Neurobiology.  Bradley RJ, Harris RA, Jenner P, Eds.  Elsevier Academic Press. pp. 54-81.

2005 Boehm SL II, Valenzuela CF, Harris RA. Alcohol: Neurobiology.  In Substance Abuse: A Comprehensive Textbook.  Lowinson J, Ruiz P, Millman R, Langrod J, Eds.  Lippincott Williams & Wilkins. pp. 121-151.

2002 Harris RA, Mascia MP, Lobo IA. Sites of Anesthetic Action on a Ligand-Gated Ion Channel.  In Molecular and Basic Mechanisms of Anesthesia.  Urban BW, Barann M, Eds.  Pabst Science Publishers. pp. 174-178.

2001 Fleming MF, Mihic SJ, Harris RA. Ethanol.  In Goodman & Gilman’s The Pharmacological Basis of Therapeutics.  Hardman & Limbird, Eds.  McGraw-Hill. pp. 429-446.

2001 Charney DS, Mihic SJ, Harris RA. Hypnotics and Sedatives.  In Goodman & Gilman’s The Pharmacological Basis of Therapeutics.  Hardman & Limbird, Eds.  McGraw-Hill. pp. 399-428.

2000 Harrison NL, Krasowski MD, Harris RA. Alcohol and general anaesthetic actions on GABAA receptors.  In GABA in the Nervous System.  Martin D, Olsen R, Eds.  Lippincott Williams & Wilkins, Philadelphia. pp. 167-189.

 

Texas Research Society on Alcoholism Seixas Award, 2010

NIAAA Keller Award, 2010

Texas Research Society on Alcoholism A Lifetime Achievement Award, 2008

Cited by Thomson Scientific, publications entered the top 1% in the field of Neuroscience and Behavior, 1997-2007

Wendy and Stanley Marsh Endowed Lectureship in Pharmacology and Neurochemistry of Substance Abuse/Addiction, 2006

Jellinek Memorial Award for outstanding contributions to alcoholism research, 2004

President, International Society for Biomedical Research on Alcoholism, 2002-2006

American Society for Information Science & Technology's list of Highly Cited Researchers, 2001

Bowles Lectureship Award, 2001

Research Society on Alcoholism Distinguished Researcher Award, 1999

Elected to American College of Neuropsychopharmacology, 1995

Department of Pharmacology Service Award, 1995

President, Research Society on Alcoholism, 1993-1995

NIAAA MERIT Award, 1989-1999

Veterans Administration Research Career Scientist Award, 1988-2002

Veterans Administration Associate Research Career Scientist Award, 1983-1988

Excellence in Teaching, School of Medicine, Class of 1980

Veterans Administration Alcoholism Research Award, 1979

National Council on Alcoholism Grant, 1978-1979

PMA Foundation Faculty Development Award, 1977-1979

PMA Foundation Research Starter Grant, 1977-1979

NIDA Postdoctoral Fellowship, 1974-1976

Neurobiology Trainee, 1971-1973

Outstanding Freshman Chemistry Student, NMSU, 1964

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    Study of the neurobiology of neurotransmitters, and the influence of alcohol and drugs of abuse on neurotransmitters.

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    Presentations and discussions of research topics in neuroscience.