Nace L GoldingDirector, Professor
Institute for Neuroscience, Department of NeuroscienceTo understand how sensory systems function and develop, using dendritic integration neurons regulate synaptic firstname.lastname@example.org
The University of Texas at Austin
Institute for Neuroscience, College of Natural Sciences
1 University Station C7000
Austin, TX 78712
Neuronal dendrites are elaborate, tree-like structures that receive up to thousands of excitatory and inhibitory synaptic connections. The morphology and electrical properties of the dendrites strongly influence the way in which synaptic activity sums together and is ultimately translated into new patterns of action potential firing in the axon. This translation process, called dendritic integration, is the fundamental means by which neurons regulate what synaptic information is communicated to the neuron's network targets. My research focuses on identifying the mechanisms by which dendrites shape synaptic activity and action potential firing, as well as understanding how these mechanisms contribute to the neuron's functional role. An additional focus is on how dendritic properties influence changes in synaptic strength that, in turn, underlie some forms of learning and memory.
We want to understand how sensory systems function and develop. We use the binaural circuitry of the auditory system as our model because of its straightforward wiring and the biophysical specializations needed for computing the relative timing of sounds to the two ears with microsecond precision.
2011 Khurana S, Remme WH, Rinzel J, Golding NL , Dynamic Interaction of Ih and IK-LVA during Trains of Synaptic Potentials in Principal Neurons of the Medial Superior Olive, Journal of Neuroscience 31: 8936-8947
2010 Mathews PJ, Jercog PE, Rinzel J, Scott LL, Golding NL., Control of submillisecond synaptic timing in binaural coincidence detectors by K(v)1 channels, Nature Neuroscience 13: 601-609 view
2010 Scott LL, Mathews PJ, Golding NL., Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive, Journal of Neuroscience 30: 2039-2050 view
2007 Scott, L.L., Hage, T.A., and Golding, N.L. , Weak action potential backpropagation is associated with high frequency axonal firing capability in principal neurons of the gerbil medial superior olive , Journal of Physiology 583: 647-661 view
2005 Scott, L.L., Mathews, P.M., Golding, N.L., Post-hearing developmental refinement of temporal processing in principal neurons of the medial superior olive. , Journal of Neuroscience 25: 7887-7895 view