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VOKES, STEVEN A
No

Steven A Vokes

Associate Professor
Molecular Biosciences


Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development

svokes@austin.utexas.edu

Phone: 512-232-8359

Office Location
MBB 1.312

Postal Address
2500 SPEEDWAY
AUSTIN, TX 78712

Postdoctoral Fellow, Harvard University 
Ph.D., University of Texas at Austin 
B.A., Swarthmore College 

Our major research interests lie in understanding the transcriptional and cis-regulatory mechanisms underlying Hedgehog signaling during embryonic development and cancer. Our experimental approach is centered on the mouse model system, where we employ a combination of genetic, molecular and genomic approaches.

Our current efforts are focused on two major questions:

  • How do transcription factors mediate Hedgehog signaling?
  • How are multiple signaling pathways integrated at the transcriptional level?

Publications:

Lex, R.K., Ji, Z., Falkenstein, K.N., Zhou, W., Henry, J.L., Ji, H. and Vokes, S.A. (2020).  GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling. eLife 9:e50670.

Liu, Z., Ramachandran, J., Vokes, S.A. and Gray, R.S. (2019). Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis. Disease Models & Mechanisms dmm041251.

Ramachandran, J., Liu, Z., Gray, R.S. and Vokes, S.A. (2019). PRMT5 is necessary to form distinct cartilage identities in the knee and long bone. Developmental Biology pii: S0012-1606(19)30376-8.

Tabler, J.M., Rigney, M.M., Berman, G.J., Gopalakrishnan, S., Heude, E., Al-Lami H., Yannakoudakis, B.Z., Fitch, R.D., Carter, C.M. Vokes, S.A. Liu, K.J., Tajbakhsh,S., Egnor, R. and Wallingford, J.B. (2017). Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx. eLife 6:e19153.

Norrie, J.L., Li, Q., Co, S., Huang, B., Ding, D., Uy, J.C., Ji, Z., Mackem, S., Bedford, M.T., Galli, A., Ji, H. and Vokes, S.A. (2016). PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development 143:4608-4619.

Human Genetics (BIO 325T)