Bob G SandersProfessor Emeritus
The University of Texas at Austin
Molecular Biosciences, College of Natural Sciences
Austin, TX 78712
Research interests are in the interdisciplinary areas of nutrition and cancer biology. Long term goals are to develop vitamin E analogs as anticancer agents, and to increase the understanding of the biological actions of vitamin E, both naturally occurring forms and synthetic analogs. Current investigations involve conducting chemotherapeutic studies with a vitamin E analog referred to as alpha-TEA, using syngeneic and xenograft preclinical animal models. Cell and molecular studies are focused on understanding signaling networks involved in alpha-TEA's pro-apoptotic and anti-survival mediated anti-cancer effects.
2014 Kline, K., W. Yu, R. Tiwary, and B. G. Sanders. Vitamin E family of compounds and cancer prevention. In: Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention. A.-N.Tony Kong, editor. CRC Press. Pages 243-260. Invited Review.
2013 Gopalan, A., W. Yu, B. G. Sanders and K. Kline. Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer Letters. 328(2):285- 296.
2012 Chen, W. S. K. Park, W. Yu, A. Xiong, B. G. Sanders, and K. Kline. Synthesis and screening of novel vitamin E derivatives for anticancer functions. European Journal of Medicinal Chemistry. 58:72-83.
2012 Gopalan, A., W. Yu, B. G. Sanders and K. Kline. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. Cancer Letters. 329(1):9-16.
2012 Gopalan, A., W. Yu, Q. Jiang, Y. Jang, B. G. Sanders and K. Kline. Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. Molecular Nutrition & Food Research. 56(12):1803-1811.
2012 Xiong, A., W. Yu, R. Tiwary, B. G. Sanders and K. Kline. Distinct role of different forms of vitamin E in DHA-induced apoptosis in triple negative breast cancer cells. Molecular Nutrition and Food Research. 56(6):923-934.
2011 Tiwary, R., W. Yu, L. A. deGraffenried, B. G. Sanders and K. Kline. Targeting cholesterol-rich microdomains to circumvent tamoxifen-resistant breast cancer. Breast Cancer Research. 13(6):R120 doi10.1186/bcr3060.
2011 Tiwary, R., W. Yu, B. G. Sanders and K. Kline. a-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. British Journal of Cancer. 104:101-109.
2011 Tiwary, R., W. Yu, B. G. Sanders and K. Kline. a-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple negative human breast cancer cells via activating p73. Breast Cancer Research. 13:R1 http://breast-cancer-research.com/content/13/1/R1.
2008 Yu W, Park SK, Jia L, Tiwary R, Scott WW, Li J, Wang P, Simmons-Menchaca M, Sanders BG, Kline K, RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling, Cancer Lett 259: 165-76
2008 Riedel SB, Fischer SM, Sanders BG, Kline K, Anticancer Drugs, Anticancer Drugs 19: 175-81
2008 Jia L, Yu W, Wang P, Li J, Sanders BG, Kline K, Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells, Prostate 68: 427-41
2007 Kline K, Lawson KA, Yu W, Sanders BG, Vitamin E and cancer, Vitam Horm 76: 435-61
2007 Wang P, Jia L, Sanders BG, Kline K, Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis, Drug Deliv 14: 497-505
2007 Wang P, Yu W, Hu Z, Jia L, Iyer VR, Sanders BG, Kline K, Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells, Mol Carcinog in press:
2006 Yu, W., M-C. Shun, K. Anderson, H. Chen, B. G. Sanders, and K. Kline, a-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells, Apoptosis 11:
2004 Kline, K., W. Yu, and B. G. Sanders, Vitamin E and Breast Cancer, Journal of Nutrition 134:
2004 Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, B.G. Sanders, and K. Kline, Comparison of vitamin E derivatives, a-TEA and VES in reduction of mouse mammary tumor burden and metastasis, Experimental Biology and Medicine 229: 954-963
2004 Anderson, K., K.A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B.G. Sanders and K. Kline, a-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis., Experimental Biology and Medicine. 229: 1169-1176