GEORGIOU, GEORGE

George Georgiou

Professor
Department of Chemical Engineering, Molecular Biosciences

Laura Jennings Turner Chair in Engineering


gg@che.utexas.edu

Phone: 512-471-6975

Office Location
CPE 4.410

Postal Address
100 E. 24th Street Stop A5000
Austin, TX 78712

Laboratory of Protein Therapeutics and Applied Immunology: Since 2009 the Georgiou laboratory has been focused on the discovery and development of protein therapeutics and on the analysis of adaptive immune responses.   Current projects include:

  • Engineering and preclinical/clinical development of human enzyme therapeutics for the treatment of solid tumors and leukemias
  • Development of methods for the molecular-level identification of the human antibody repertoire in blood and in secretions
  • Analysis of the antibody repertoire elicited by viral infection (e.g. HIV-1) and vaccination to aid the development of more efficient vaccination stategies
  • Engineering of antibody therapeutics displaying enhanced ability to recruit cytotoxic leukocytes and blood proteins (complement) for the effective clearance of pathogens

Earlier work by the Georgiou lab had focused on redox homeostasis and protein biogenesis in bacteria and on the development of platform technologies for protein expression and engineering. These studies led to a number of mechanistic advances and to new technologies that are being used commercially for therapeutic protein manufacturing and protein engineering. 

Dr. Georgiou is co-inventor of 29 issued and 52 pending US patents and . Notably, 16 different technology suites (comprising either one or multiple patents) have been licensed to major pharmaceutical and biotechnology companies

Select Recent Publications

Doria-Rose, N.A… Georgiou, G.… P.D. Kwong and J.R. Mascola, “Developmental Pathway for Potent V1V2-Directed HIV-1-Neutralizing Antibodies,”  Nature (in press, 2014)

Georgiou G., Ippolito, G., Beuasang, G., Busse, C.E., Wardemann, H. and S.R. Quake, “The Promise and Challenge of High-throughput Sequencing of the Antibody Repertoire,” Nature Biotechnol. 32:158-68 (2014)

Quandt, E.M., Deatherage, D.E., Ellington, A.D., Georgiou, G. and J. E. Barrick, “Recursive

Genome-Wide Recombination and Sequencing Reveals a Key Refinement Step in the

Evolution of a Metabolic Innovation in E. coli,”  Proc. Natl. Acad. Sci. USA 111:2217-22 (2014)

Lavinder, J., Wine, Y., Giesecke, C., Ippolito, G.C., Horton, A.P., Hoi, K.-H., DeKosky, B.J.,

Ellington, A.D., Dörner, T., Marcotte, E.M., Boutz, D.R. and G. Georgiou,  “Dynamics, Functionality and Discordance of the Human Serum Antibody and BCR Repertoires Following Immunization” Proc. Natl. Acad. Sci. USA 111:2259-64 (2014)

Li, Y., Gebhard, M.C., Qing, L., Georgiou, G. and B.L. Iverson, B.L.,  “Engineering of Novel TEV Protease Variants by Yeast ER Sequestration Screening (YESS) of Combinatorial Libraries” Proc. Natl. Acad. Sci. USA 110:7229-34 (2013)

DeKosky, B.J., Ippolito,G.C., Deschner,R.P., Lavinder,J.J., Rawlings,M.P., Varadarajan,N., Wine, Y., Giesecke,C., Dörner,T., Andrews, S.F., Wilson,P.C., Hunicke-Smith, S.P., Wilson, C.P., Ellington, A.D. and G. Georgiou, “High Throughput Determination of the Antibody VH:VL Paired Repertoires,” Nature Biotechnol. 31:166-69 (2013)

Wine, Y., Boutz, D.R., Lavinder, J.J., Horton, A., Miklos, A.E., Hughes, R.A., Jung, S.T, Murrin E.M., Ellington, A.D., Marcotte, E.M. and G. Georgiou,  “Molecular Deconvolution of the Monoclonal Antibodies that Comprise the Polyclonal Serum Response,” Proc. Natl. Acad. Sci. USA 110: 2993-8 (2013) PMID: 23382245

Jung, S. T., Kelton, W., Kang, T. H.; Ng, D., Anderssen, J. T.; Sandlie, I., Sarkar, C., G. Georgiou, "Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High FcγRIIa Affinity and Selectivity" ACS Chem. Bio. 8:368-75 (2013)

Stone, E.M., Paley, O., Hu, J., Ekerdt, B.; Cheung, N.-K. and G. Georgiou, “De novo Engineering of a Human Methionine-γ-Lyase for Systemic L-Met Depletion Cancer Therapy,” ACS Chem. Bio. 7:1822-9 (2012) 

  • Select Honors, Awards

         2010           Institute of Medicine (IOM) of the National Academies

         2008           Elected as one of 100 Eminent Chemical Engineers of the Modern Era, American Institute of Chemical Engineers (AIChE)

         2007           AMGEN Award in Biochemical Engineering

         2005           National Academy of Engineering  (NAE)

         2004           Fellow, American Association for the Advancement of Science

         2004           Fellow, American Academy of Microbiology

         2003           Professional Progress Award for Outstanding Progress in Chemical Engineering, AIChE

     2003           Marvin J. Johnson Award in Microbial and Biochemical Technology, American Chemical Society

     1996            Fellow, American Institute for Biological and Medical Engineers (AIMBE)

         1995            E. Bergman Award US-Israel Bi-national Science Foundation