Seongmin LeeAssociate Professor
College of Pharmacy
Fellow of Jaime N. Delgado Endowed Professorship in Pharmacyseongminlee@austin.utexas.edu
The University of Texas at Austin
PO Box F
Austin, TX 78713
The unifying theme of the Lee lab is the elucidation of molecular mechanisms underlying genome/epigenome management using toolkits of biochemistry, chemical and structural biology. In particular, we are interested in how DNA repair and epigenetic regulation maintain genomic and epigenomic integrity. Our current research interests include base-excision DNA repair, single-strand break DNA repair, and epigenetic regulation.
Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β (2014) J Am Chem Soc 136, 5709-5721.
Structural basis for the promutagenicity of 8-bromoguanine (2014) J Biol Chem 289, 6289-6298.
Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4 (2013) Steroids 79, 938-944.
Discovery of hypoiodite-mediated aminyl radical cyclization lacking a nitrogen radical-stabilizing group: Application to synthesis of an oxazaspiroketal-containing cephalostatin analog (2011) Org Lett 13, 4766-4769.
Structure of Escherichia coli AlkA in Complex with Undamaged DNA (2010) J Biol Chem 285, 35783-91.
Atomic Substitution Reveals the Structural Basis for Substrate Adenine Recognition and Removal by Adenine DNA Glycosylase. (2009) Proc Natl Acad Sci USA 106, 18497-502.
Trapping and structural elucidation of a very advanced intermediate in the lesion-extrusion pathway of hOGG1 (2008) J Am Chem Soc 130, 7784-5.
Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine (2008) J Am Chem Soc 130, 11570-1.