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Lee, Seongmin

Seongmin Lee

Associate Professor
College of Pharmacy, Department of Oncology

Jaime N. Delgado Endowed Professorship in Pharmacy


seongminlee@austin.utexas.edu

Phone: 512-471-1785

Office Location
PHR

Postal Address
2409 UNIVERSITY AVE
AUSTIN, TX 78712

The unifying theme of the Lee lab is the elucidation of molecular mechanisms underlying genome/epigenome management using toolkits of biochemistry, chemical, and structural biology. In particular, we are interested in how DNA repair and epigenetic regulation maintain genomic and epigenomic integrity. Our current research interests include translesion DNA synthesis, DNA interstrand cross-links, and epigenetic regulation.

Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4. Biochem J. 2020, 477, 2859-2871.

Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4. Biochem J. 2020, 477, 1601-1612

Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine. Nucleic Acids Res. 2020, 48, 5119-5134.

Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion. Biochem J. 2020 477, 937-951.

Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η. Molecules 2019, 24, 3928

Mutagenic replication of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine by human DNA polymerases. J. Am. Chem. Soc. 2019, 141, 4584-4596

Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η.  Biochem J. 2019, 476, 747-758

Promutagenicity of 8-chloroguanine, a major inflammation-induced halogenated DNA lesion. Molecules 2019, 24, 3507

Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase β.  Biochem J. 2018, 475, 571-585.

Synthesis of 23-deoxy-25-epi north unit of cephalostatin 1 via reductive and oxidative modifications of hecogenin acetate. Steroids 2017, 118:68-75

N7 Methylation alters base-pairing patterns of guanine. J. Am. Chem. Soc. 2015, 137, 14067-14070.

Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β J. Am. Chem. Soc. 2014136, 5709-5721.

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β. Nucleic Acids Res. 2014, 42, 11233-12245.

Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine. Nucleic Acids Res. 2014, 42, 8755-8766.