Lydia M ContrerasAssistant Professor
Department of Chemical Engineering
Chevron Centennial Teaching Fellow in Chemical Engineeringlcontrer@che.utexas.edu
The University of Texas at Austin
Department of Chemical Engineering, Cockrell School of Engineering
1 University Station C0400
Austin, TX 78712
Our research combines biomolecular engineering, genetic studies and computational modeling to understand molecular features that lead to the specific recognition and interaction of RNAs and proteins. We apply fundamental concepts that emerge from experimental (and computational) work to develop novel applications that could beneficially impact human health and biotechnology. Overall research interests: * RNA-protein interactions, RNA-protein folding * Novel molecular tools for intracellular studies of RNA-metabolism * Molecular engineering for new cellular behaviors * Diagnostics for RNA-related diseases * Molecular mechanisms of stress-responses
Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis. (2010) Nucleic Acids Res. 38(12), 4067-78.
Intracellular ribosome display via SecM translation arrest as a selection for antibodies with enhanced cytosolic stability. (2007) J Mol Biol. 372(2), 513-24.
Protein translocation through a tunnel induces changes in folding kinetics: a lattice model study. (2006) Biotechnol Bioeng. 94(1), 105-17.
In silico protein fragmentation reveals the importance of critical nuclei on domain reassembly. ( 2008) Biophys J. 94(5), 1575-88.