Mukhopadhyay, Somshuvra

Somshuvra Mukhopadhyay

Assistant Professor
College of Pharmacy


Metal ion homeostasis, membrane trafficking, mechanisms of neurologic and infectious diseases

som@austin.utexas.edu

Phone: 512-232-8200

Office Location
BME 3.510E

Postal Address
The University of Texas at Austin
College of Pharmacy
1 University Station A1900
Austin, TX 78712

Current:

Assistant Professor
Division of Pharmacology & Toxicology; Institute for Cellular & Molecular Biology; and Institute for Neuroscience,
The University of Texas at Austin
Austin, TX 78712.

 

Education & Training:

1. Post-doctoral Fellow with Dr. Adam Linstedt: Carnegie Mellon University, Pittsburgh, PA. Aug 2008 - Jan 2013.

2. Ph.D. in Cell Biology with Dr. Pravin Sehgal: New York Medical College, Valhalla, NY. Aug 2004 - May 2008.

3. M.B.B.S. (Bachelor of Medicine, Bachelor of Surgery): Topiwala National Medical College, Mumbai, India. Aug 1998 - April 2004 (M.B.B.S. is equivalent to M.D. in the USA).

 

Research Interest:  The focus of our studies is to understand the cell biology of human disease. Currently, we have two major projects: 

1. Parkinsonism and metal homeostasis: Metals, such as iron, manganese, and copper, are essential for life, but become toxic at elevated levels and cause severe neurological diseases, such as parkinsonism. A major goal is to understand the mechanisms by which cells and organisms maintain homeostatic control of essential metals, and by which changes in these homeostatic pathways, secondary to genetic or environmental insults, lead to parkinsonism.

2. Intracellular trafficking of Shiga and related bacterial toxins: Bacteria that produce Shiga and related toxins affect millions each year. Antidotes for these toxins are not available, and this severely limits treatment options. The goal of this project is to determine the mechanisms by which these bacterial toxins invade cells to cause diease, and to design therapeutically viable small molecule inhibitors of toxin transport.

Please view our lab website to read more about our research, publications, and available positions. 

Publications relevant to on-going work in the lab:

  1. Zogzas CE, Aschner M, Mukhopadhyay S. Structural elements in the transmembrane and cytoplasmic
    domains of the metal transporter SLC30A10 are required for its manganese efflux activity. J Biol Chem 291:15940-15957, 2016.
  2. Selyunin AS, Mukhopadhyay S. A conserved structural motif mediates retrograde trafficking of Shiga toxin types 1 and 2. Traffic 16: 1270-1287, 2015.
  3. Levya-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S. SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity. J Neurosci 34: 14079-14095, 2014. [This manuscript was highlighted in Nature Chemical Biology 10:984, Dec 2014 and featured in The Academic Minute, a program of National Public Radio].
  4. Mukhopadhyay S, Linstedt AD. Retrograde trafficking of AB5 toxins: mechanisms to therapeutics. J Mol Med 91: 1131-1141, 2013 (Invited Review).
  5. Mukhopadhyay S, Redler B, Linstedt AD. Shiga toxin binding site for host cell receptor GPP130 reveals unexpected divergence in toxin trafficking mechanisms. Mol Biol Cell 24:2311-2318, 2013.
  6. Mukhopadhyay S, Linstedt AD. Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis. Science 335: 332-335, 2012. [This manuscript was highlighted in Nature (Nature 481:413, 2012; Research Highlights section); had an associated commentary in Science, and was featured in numerous national and international news websites including The Washington Post and MSNBC]. 
  7. Mukhopadhyay S, Linstedt AD. Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity. Proc Natl Acad Sci USA 108: 858-863, 2011.
  8. Mukhopadhyay S, Bachert C, Smith DR, Linstedt AD. Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130. Mol Biol Cell 21: 1282-1292, 2010.
  1.       NIH "Outstanding New Environmental Scientist (ONES)" R01, Jan 2016-Dec 2020.
  2.       NIH K99/R00 “Pathway to Independence”, Dec 2011–Mar 2017.
  3.       Post-doctoral Fellowship, American Heart Association, 2011.
  4.       Pre-doctoral Fellowship, American Heart Association, 2007-2008.
  5.       Grant-in-Aid of Research, Sigma Xi, the Foundation for Scientific Research, 2007.
  6.       Grant-in-Aid of Research, American Foundation for Aging Research, 2007.
  7.       Graduate Faculty Council Award, New York Medical College, May 2008.
  1. Fundamentals of fluorescence microscopy - Course director. This course provides a complete overview of fluoresence microscopy. Enrollment is limited to advanced graduate students. Students get a background in the theoretical principles of microscopy, including how different types of confocal microscopes function; hands-on experience in diverse microscopy techniques; and have the opportunity to meet with industrial faculty from leading microscope and camera manufactures such as Nikon and Andor.