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VOKES, STEVEN A
No

Steven A Vokes

Associate Professor
Molecular Biosciences


Understanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate development

svokes@austin.utexas.edu

Phone: 512-232-8359

Office Location
MBB 1.312

Postal Address
2500 SPEEDWAY
AUSTIN, TX 78712

Dr. Vokes graduated from Swarthmore College with a Bachelor of Arts in Biology and received his doctoral degree in Molecular Biology from the University of Texas at Austin, examining the process of blood vessel formation during early embryonic development under the supervision of Dr. Paul Krieg. As a postdoctoral fellow at Harvard University, he studied developmental genetics and genomics in Dr. Andy McMahon's laboratory and was the recipient of Helen Hay Whitney and Charles A. King postdoctoral fellowships. He joined the faculty at UT Austin in 2008 and is currently an Associate Professor in the Department of Molecular Biosciences. His research, supported by the National Institute for Health, investigates how transcriptional repressors, especially those underlying Hedgehog signaling, interface with chromatin to regulate gene expression.

The Vokes lab investigates how transcriptional repressors, especially those underlying Hedgehog signaling, interface with chromatin to regulate gene expression. We study these responses during development, homeostasis and regeneration. Our experimental approach is centered on the mouse model system in a variety of contexts, including the developing limb, knee and larynx, where we employ a combination of genetic and genomic approaches.

Publications:

Lex, R.K., Ji, Z., Falkenstein, K.N., Zhou, W., Henry, J.L., Ji, H. and Vokes, S.A. (2020).  GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling. eLife 9:e50670.

Liu, Z., Ramachandran, J., Vokes, S.A. and Gray, R.S. (2019). Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis. Disease Models & Mechanisms dmm041251.

Ramachandran, J., Liu, Z., Gray, R.S. and Vokes, S.A. (2019). PRMT5 is necessary to form distinct cartilage identities in the knee and long bone. Developmental Biology pii: S0012-1606(19)30376-8.

Tabler, J.M., Rigney, M.M., Berman, G.J., Gopalakrishnan, S., Heude, E., Al-Lami H., Yannakoudakis, B.Z., Fitch, R.D., Carter, C.M. Vokes, S.A. Liu, K.J., Tajbakhsh,S., Egnor, R. and Wallingford, J.B. (2017). Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx. eLife 6:e19153.

Norrie, J.L., Li, Q., Co, S., Huang, B., Ding, D., Uy, J.C., Ji, Z., Mackem, S., Bedford, M.T., Galli, A., Ji, H. and Vokes, S.A. (2016). PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development 143:4608-4619.

Human Genetics (BIO 325T)