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Contreras, Lydia

Lydia M Contreras

Associate Professor
Department of Chemical Engineering, Cockrell School of Engineering

Jim and Barbara Miller Endowed Faculty Fellowship in Chemical Engineering


lcontrer@che.utexas.edu

Phone: 512-471-2453

Office Location
CPE

Postal Address
200 E DEAN KEETON ST
AUSTIN, TX 78712

Our research combines biomolecular engineering, genetic studies and computational modeling to understand molecular features that lead to the specific recognition and interaction of RNAs and proteins. We apply fundamental concepts that emerge from experimental (and computational) work to develop novel applications that could beneficially impact human health and biotechnology. Overall research interests: * RNA-protein interactions, RNA-protein folding * Novel molecular tools for intracellular studies of RNA-metabolism * Molecular engineering for new cellular behaviors * Diagnostics for RNA-related diseases * Molecular mechanisms of stress-responses

Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis. (2010) Nucleic Acids Res. 38(12), 4067-78.

Intracellular ribosome display via SecM translation arrest as a selection for antibodies with enhanced cytosolic stability. (2007) J Mol Biol. 372(2), 513-24.

Protein translocation through a tunnel induces changes in folding kinetics: a lattice model study. (2006) Biotechnol Bioeng. 94(1), 105-17.

In silico protein fragmentation reveals the importance of critical nuclei on domain reassembly. ( 2008) Biophys J. 94(5), 1575-88.